Gordon Townsend (Colin Quinn) is telling his two young daughters Amy (Devin Fabry) and Kim (Carla Oudin) that he and their mother are divorcing because monogamy is not realistic, repeating it like a mantra. Twenty-three years later, Amy (Amy Schumer) is a party girl who drinks too much, smokes weed and sleeps around while dating a gym-addict named Steven (John Cena). Amy writes for a men’s magazine and her cold-hearted strict boss, Dianna (Tilda Swinton), assigns her to write an article about a sports doctor named Aaron Conners (Bill Hader).